Scientists have created a complete map showing how hundreds of possible mutations in a key cancer gene influence tumor growth. The study focused on CTNNB1, a gene that produces the protein β-catenin, ...

Co announced that compounds from its Beta-catenin pathway inhibitor program demonstrated significant tumor growth inhibition in multiple animal models. The results will be presented today at the ...

Dental pulp regeneration remains a major clinical challenge. Researchers have discovered that SMAD7 directly forms a ...

Dental pulp injury caused by trauma or deep caries often leads to inflammation, tissue necrosis, and eventual loss of tooth ...

ST316 interfered with β-catenin immune-exclusion allowing for stronger cytotoxic T-cell activity. The Food and Drug Administration (FDA) has granted Orphan Drug designation to ST316 for the treatment ...

Phase 1/2 study of the HER3-directed antibody-drug conjugate patritumab deruxtecan (MK-1022) as monotherapy in patients with gastrointestinal cancers. This is an ASCO Meeting Abstract from the 2025 ...

Researchers at Tufts University School of Medicine and the Graduate School of Biomedical Sciences (GSBS) have identified a small molecule that, in mouse and human cell models, rectifies the underlying ...